Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats

Authors

  • Shakeri, Nader Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran
  • Shams, Zahra Faculty of Physical Education and Sports Sciences, Central of Tehran, Islamic Azad University, Tehran
  • Fakhari Rad , Fatimah Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran
  • ramezani fard, nasrin Young Researchers and Elites club, Science and Research Branch, Islamic Azad University, Tehran
  • Soltanian, Zahra Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran
  • Vanaky, Behnaz Faculty of Physical Education and Sport Sciences, Tehran University, Tehran
Abstract:

  Introduction: Type 2 diabetes has many complications, including cardiovascular disease, which is associated with an increase in inflammatory biomarkers. Research has shown that physical activity can reduce inflammatory factors and improve cardiovascular disease. The purpose of this study was to investigate the effect of resistance exercise on some of the inflammatory and anti-inflammatory factors in the heart tissue of type 2 diabetic rats. Methods: In this study, 18 male rats were selected. Rats were diabetic with nicotinamide and streptozotocin (stz) and then randomly divided into 2 groups of control (n=9) and training (n=9). The training group performed a resistance training program for 8 weeks, 5 days a week. Measurement of TNF-α and IL10 expression in the heart tissue was determined using the one step SYBR TAKARA single-step kit. To compare the difference between the mean of variables between exercise and control groups, independent t-test and t-test were used also to determine the effect of diabetes induction on variables. To determine the relationship between variables, Pearson correlation coefficient and separation correlation coefficient were used. Data were analyzed by SPSS software version 22. Results: The results showed that the insulin resistance index decreased significantly in the training group compared to the control group. On the other hand, the expression of TNF-α gene decreased and IL10 showed a significant increase (α≤0.05). Conclusion: The results indicate that resistance training may be effective in modulating the inflammatory factors of TNF-α and IL10 in the heart tissue of type 2 diabetic rats.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

The effect of eight weeks’ endurance training and stevia supplement on ANP and b-MHC gene expression of heart tissue in type 1 diabetic rats

Background: The beneficial effects of exercise and stevia extract have been reported to improve diabetes-related indicators. However, the cardiac benefits of exercise and stevia extract in type 1 diabetes are unclear. Objective: The aim of this study was to evaluate the effect of eight weekschr('39') endurance training and stevia supplement on ANP and b-MHC gene expression of heart tissue in t...

full text

Effect of Eight-Week High Intensity Interval Training on Omentin-1 Gene Expression and Insulin-Resistance in Diabetic Male Rats

Background. Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin-resistance and obesity. Objective(s). The aim of this study was to investigate the effect of eight weeks of high-intensity interval training on omentin-1 gene expression in visceral adipose tissue and insulin-resistance in male wistar rats. Methods. A total of 26 male Wis...

full text

The Effect of 6 Weeks Resistance Training and High-Intensity Interval Training on Glut-4 Gene Expression of Diabetic Rats

Objective: GLUT4 glucose transporter content and glucose transport capacity are closely correlated in muscle. The purpose of current study was to evaluate the effect of 6 weeks of resistance training and High-Intensity Interval Training (HITT) on Glut-4 gene expression in type 2 diabetes mellitus (T2DM) by high fat diet and STZ. Materials and Methods: This study was done on 32 male Wistar in B...

full text

Effect of Eight Weeks of Cardiac Rehabilitation Training on PPAR-α Gene Expression in CABG Patients

ABSTRACT             Background and objectives: Cardiovascular disease is the leading cause of death worldwide. This study examined the effects of cardiac rehabilitation exercise on lipid profile and expression of peroxisome proliferator-activated receptor alpha (PPAR-α) gene in patients who underwent coronary artery bypass grafting....

full text

THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF- Α IN DIABETIC MALE RATS

Background: The proinflammatory cytokines of tumor necrosis factor alpha TNF-α and anti-inflammatory interleukin-10 have important roles in inducing and preventing systemic inflammation, respectively. The purpose of this study was to the synergistic effect of High-Intensity Interval training and resveratrol consumption on IL-10 and TNF- α in diabetic rats. Methods: In this experimental study, ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 6

pages  1656- 1667

publication date 2019-10

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023